Clinical Outcomes of Recurrent Intracranial Meningiomas Treated with Proton Beam Reirradiation.
Brandon S. Imber, Brian Neal, Dana L. Casey, Heba Darwish, Andrew L. Lin, Oren Cahlon, Brian Chon, Henry Tsai, Eugen Hug, Yoshiya Yamada, and T. Jonathan Yang (2019) International Journal of Particle Therapy: Spring 2019, Vol. 5, No. 4, pp. 11-22.
Proton beam radiation therapy (PBRT) offers a dosimetric advantage for reRT, especially for patients with multiple prior courses of RT, owing to improved ability to spare toxicity to nearby normal structures.
PBRT reRT may be a relatively efficacious strategy for recurrent meningiomas, a patient population lacking durable therapeutic options. Even with significant prior radiation exposure, radionecrosis rates appear low. We feel that prospective investigation of the modality is warranted to validate incremental improvement over traditional photon RT.