The relationship between radiation doses to coronary arteries and location of coronary stenosis requiring intervention in breast cancer survivors

Anna-Karin Wennstig, Hans Garmo, Ulf Isacsson, Giovanna Gagliardi, Niina Rintelä, Bo Lagerqvist, Lars Holmberg, Carl Blomqvist, Malin Sund and Greger Nilsson

Radiation Oncology201914:40

This study assessed the relationship between radiation doses to the coronary arteries (CAs) and location of a coronary stenosis that required intervention after three-dimensional conformal radiotherapy (3DCRT) for breast cancer (BC).

In women receiving conventional 3D Conformal RadioTherapy for Breast Cancer between 1992 and 2012, radiation doses to the Left Anterior Descending Artery (LAD) remained high and were associated with an increased requirement of coronary intervention in mid LAD. The results support that the LAD radiation dose should be considered in RT treatment planning and that the dose should be kept as low as possible.

Reducing the dose to LAD, and implementation of heart-sparing RT techniques is of importance, since minimising the dose to LAD is expected to diminish the risk of later radiation-induced stenosis.

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